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ABSTRACT. The present study aimed to evaluate the in vitro antimicrobial activity of pharmacologically important Adhatoda vasica plant extracts. Plant Adhatoda vasica L. Nees (Acanthaceae) commonly known as Malabar nut is an evergreen two – three m tall shrub, sometime used as. Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India. The alkaloid Vasicine was isolated from ethanolic extract of the .

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Streptomycin was used as positive control for bacteria and Ketoconazole as positive control for fungi. Investigation on antifeedant and anthelmentic potential of Adhatoda vasica nees. Minimum inhibitory concentration studies of the compounds were performed according to the standard reference methods for bacteria [ 17 ] and filamentous fungi [ 18 ]. Journal List Biomed Res Int v. Table 4 Cytotoxic effect of Vasicine acetate against A lung adenocarcinoma cancer cell line.

Cytotoxic A and antimicrobial effects of Methylobacterium sp. Glossary of Indian Medicinal Plants. Handbook of Ayurvedic Medicinal Plants. The crude extract of A. Kulkarni [ 24 ] reported that A. National Center for Biotechnology InformationU. Ignacimuthu and Shanmugam [ 15 ] have reported the antitubercular activity of Vasicine acetate isolated from A. Antibacterial and antifungal activities were carried out using disc diffusion method [ 16 ].


Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Table 2 Minimum inhibitory concentration of Vasicine acetate against tested bacteria antimicronial fungi. Antitussive effect of Adhatoda vasica extract on mechanical or chemical stimulation-induced coughing in animals. Classical Uses of Medicinal Plants. After various durations of cultivation, the solution in the medium was removed. Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Ness.

Materials and Methods 2. Balachandran2 S. Microbial Organisms The following Gram negative, Gram positive bacteria, clinical isolates, and fungi were used for the experiment: Acanthaceae is used in the indigenous system of medicine in India.

BoxRiyadhSaudi Arabia. The extract was filtered through Whatman No. A voucher specimen No. The alkaloid Vasicine was isolated from ethanolic extract of the leaves of A. Vasicine acetate showed moderate antibacterial activity compared to Vasicine. The estimation of Vasicine acetate content in the extract was performed using linear regression analysis. BHT is used as standard of antioxidant.

The antifungal agent Ketoconazole for fungi and antibacterial agent Streptomycin for bacteria were included in the assays as positive controls. The ethanol extract of A. Author information Activvity notes Copyright and License information Disclaimer.

The physical and spectroscopic data were compared with those reported in the literature [ 15 ].


Antibacterial activity of adhatoda vasica leaf extract

All melting point values are uncorrected and taken by open capillary method on a heating block Instrument. HPLC chromatograms of the ethanol extract of the leaves of Adhatoda vasica. Mobile phase A consisted of water with 0. Vasicine acetate could be probed further in drug discovery programme.

It was then distilled on a water bath and the residue was washed with little n-hexane. The following Gram negative, Gram vasida bacteria, clinical isolates, and fungi were used for the experiment: International Journal of Green Pharmacy. International Journal of Cancer.

The plant contains alkaloids such as Vasicine, vasicinone, deoxyvasicine, vasicol, adhatodinine, and vasicinol [ 12 ]. Sample ethanol extract Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper. Vasicine is reported to have bronchodilatory, respiratory stimulant, and uterine stimulant effects [ 14 ]. The plant vasixa used in the indigenous system of medicine in India and is a well-known expectorant in both Ayurvedic and Unani Systems of Medicine [ 45 ].