ERTAPENEM PACKAGE INSERT PDF

ERTAPENEM PACKAGE INSERT PDF

Oct 7, 2020 Environment by admin

For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

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Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. In setting of packagf cat or dog bite, preemptive antimicrobial therapy is recommended for 3 to 5 days for patients who are immunocompromised, asplenic, have advanced liver disease, have edema of the bite area, have moderate to severe injuries, particularly of the hand or face, or have penetrating injuries to the periosteum or joint capsule.

A supplemental dose may or may not be required following dialysis.

Ertapenem Sodium Injection – Par Sterile Products – Products

Use within 1 hour after preparation. Ertapenem exhibits bactericidal activity due inhibition of cell wall synthesis mediated via binding to penicillin binding proteins PBPs. Patients should be told to complete the full course of treatment, even if they feel better earlier. In some instances, this effect is used therapeutically to increase availability of the antimicrobial agent.

In milder cases, the colitis may respond to discontinuation of the offending agent. Valproic Acid, Divalproex Sodium: During clinical studies, seizures occurred in 0. Lidocaine is the diluent for IM administration of ertapenem. PAE is defined as the suppression of bacterial growth that continues after the antibiotic concentration falls below the bacterial MIC. Dilute the entire contents of the reconstituted vial in 50 mL of 0.

Ertapenem for Injection

Ertapenem is not a substrate for P-glycoprotein mediated transport. Additionally, increased monitoring of the INR, especially during initiation and upon discontinuation of the antibiotic, may be necessary.

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The IM reconstituted formulation is not for IV use. Sodium picosulfate; Magnesium oxide; Anhydrous citric acid: Carbapenems can reduce serum concentrations of valproic acid to subtherapeutic levels when the two drugs are administered together.

Invanz (ertapenem) dose, indications, adverse effects, interactions from

Major Prior or concomitant use of antibiotics with sodium picosulfate; magnesium oxide; anhydrous citric acid may reduce efficacy of the bowel preparation as conversion of sodium picosulfate to its active metabolite bis- p-hydroxy-phenyl -pyridylmethane BHPM is mediated by colonic bacteria.

PBPs are responsible for several steps in the synthesis of the cell wall and are found in quantities of several hundred to several thousand molecules per bacterial cell. For the treatment of acute pelvic infections, including postpartum endomyometritis, septic abortion, and postsurgical gynecologic infections. Available data from a small number of postmarketing cases with ertapenem use in pregnancy are insufficient to inform any drug-associated risks for major birth defects, miscarriage, or adverse maternal or fetal outcomes.

IM use is contraindicated in patients with an amide local anesthetic hypersensitivity. Infants and Children 3 months to 12 years. Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. For 1 g dose: However, it is theorized that a combination of resistance mechanisms is required for significant carbapenem resistance.

Prescribing ertapenem in the absence of a proven or strongly suspected bacterial infection or for a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

erhapenem Carbapenem hypersensitivity, cephalosporin hypersensitivity, penicillin hypersensitivity. The MICs are defined for Enterobacteriaceae as susceptible at 0. Reconstitute each 1 g vial with 10 mL of 0. Minor Probenecid inhibits the renal excretion of ertapenem by competing with them for active tubular secretion.

No dosage adjustment needed. Intravenous or Intramuscular dosage.

One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported.

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Products inhibiting peristalsis are contraindicated in this clinical situation. Reconstitute ertxpenem 1 g vial with 3. If focal tremor or myoclonic seizures occur, patients should be evaluated neurologically. It inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to specific penicillin-binding proteins PBPs that are located inside the bacterial cell wall. It is eliminated via the kidney with a prolonged half-life of roughly 4. There is a maximum proportion of PBPs that can be acylated; therefore, once maximum acylation has occurred, killing rates cannot increase.

Immediately withdraw the appropriate dose and inject deeply into a large muscle i.

Antibiotics are non-selective and may result in the eradication of beneficial microorganisms while promoting the emergence of undesired ones, causing secondary infections such as oral thrush, colitis, or vaginitis. It exhibits non-linear pharmacokinetics due to a high level of concentration-dependent plasma protein binding to albumin. In vitro and in vivo animal studies have demonstrated that the major pharmacodynamic parameter that determines efficacy for beta-lactams is the amount of time free non-protein bound drug concentrations exceed the minimum inhibitory concentration MIC of the organism free T above the MIC.

Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.

No intraoperative redosing and duration of prophylaxis less than 24 hours are suggested by clinical practice guidelines. In vitro studies have also shown that it does not inhibit p-glycoprotein-mediated transport of digoxin or vinblastine. It was previously thought that antibiotics may decrease the effectiveness of OCs containing estrogens due to stimulation of metabolism or a reduction in enterohepatic circulation via changes in GI flora.

FDA-approved dosage in renal failure for adults: For less than 1 g dose: