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See package insert. How to take and store Felbamate? Follow your doctor’s directions. Call if you have any questions. Usually, your doctor will tell you to start by. Felbatol is the brand name used in the United States for felbamate. Read the black box warning in the Package Insert to your patient and obtain any necessary . Felbamate, also known as Felbatol, has been approved by the Food and Drug about all potential risks before using this drug and read the package insert.

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Felbatol (felbamate) dose, indications, adverse effects, interactions from

The intended therapeutic effect of clarithromycin felbamatf be decreased. Major Bupropion should not be used by patients taking anticonvulsants for seizures because it may decrease the seizure threshold. Isavuconazole, the active moiety of isavuconazonium, is a sensitive substrate of the hepatic isoenzyme CYP3A4; felbamate is an inducer of this enzyme. In addition, significant signs and symptoms of toxicity can occur at normal or low serum concentrations, and symptom control for seizures or behavior can occur at subtherapeutic serum concentrations.

It is thought that hepatic failure in felbamate-treated patients greatly exceeds that which occurs in the general population. Felbamate is contraindicated in patients with current or previous hepatic disease or dysfunction e.

Moderate The phenothiazines, when used concomitantly with anticonvulsants, can lower the seizure threshold. Oral anticonvulsant agent chemically similar to meprobamate, but does not possess muscle-relaxant activity. Data were analyzed from drugs with adequately designed clinical trials including carbamazepine, felbamate, gabapentin, lamotrigine, felbamatr, oxcarbazepine, pregabalin, tiagabine, topiramate, valproate, and zonisamide.


Routine laboratory testing of the blood cannot be reliably used to reduce the incidence of aplastic anemia. Moderate Concurrent administration of felbamate velbamate other antiepileptic drugs results in changes in serum concentrations of both felbamate and the antiepileptic drugs. Felbamate is contraindicated in patients with a felbamate or carbamate hypersensitivity.

Concurrent use may decrease the plasma concentrations of cobicistat, leading to a reduction of antiretroviral efficacy and the potential development of viral resistance. If seizures occur, amphetamine discontinuation may be necessary. Coadministration of etoposide with a strong CYP3A4 inducer phenytoin resulted in increased etoposide clearance and reduced efficacy, as did coadministration with a felbamae inducer of CYP3A4 and P-glycoprotein P-gp valproic acid. Therapeutic drug insegt is not required or available for most anticonvulsants.

Clinical studies did not include sufficient numbers of patients 65 years of age and older to determine whether they respond differently to felbamate than younger adults. Among felbamate-treated patients, aplastic anemia occurs at an incidence that may be more than fold greater than that seen in the untreated population e. In addition, monitor patients receiving lacosamide via the intravenous route closely. Your Name Your name is required.

Adequate dosages of anticonvulsants should be continued when a phenothiazine is added. The effect of felbamate on labor and delivery in humans is unknown.

Monitor concentrations of normethsuximide in patients treated with methsuximide and felbamate. It is similar for both the tablets and suspension. Prior to this request, preliminary evidence had suggested a possible link between anticonvulsant use and suicidality. Moderate Concomitant use of felbamate and methsuximide may result in increased plasma concentrations of normethsuximide.

Moderate A dosage reduction of clobazam may be necessary during co-administration of felbamate.


Moderate Caution is advised when administering elbasvir; grazoprevir with felbamate. Regular ingestion of ethanol followed by abrupt discontinuation can provoke seizures. Guidance is not available regarding concomitant felbamaet of cobimetinib with weak CYP3A inducers.

Moderate Consider a dose reduction of cannabidiol if coadministered with felbamate.

For the treatment of partial and felgamate seizures associated with Lennox-Gastaut syndrome in children. Major Coadministration of felbamate with cobicistat is not recommended. Patients must call to enroll in the registry. Moderate Concomitant administration of alprazolam with CNS-depressant drugs, including anticonvulsants, can potentiate the CNS effects of either agent.

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Your email has felbzmate sent. Concomitant use may result in decreased plasma concentrations of dronabinol.

There were 4 completed suicides among patients in drug treatment groups versus none in the placebo groups. Felbamate may interfere with valproic acid metabolism and should be administered cautiously to patients receiving valproic acid. To minimize potential for interactions, consider administering oral anticonvulsants such as felbamate at least 1 hour before or at least 4 hours after colesevelam. Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide: No systematic studies of felbamate in geriatric patients have been conducted.

Monitor for decreased clinical effects of tretinoin, ATRA while receiving concomitant therapy. Physicians are advised to recommend that pregnant patients receiving felbamate enroll in the North American Antiepileptic Drug NAAED Pregnancy Registry to provide information about the effects of in utero exposure to the drug.