Apr 2, 2022 History by admin

Justicia secunda Vahl belonging to the family Acanthaceae is known as “Blood root” and “Sanguinaria” in Barbados and Venezuela respectively. The folkloric. Justicia secunda Vahl (Acanthaceae), a native tropical herbaceous plant originating from South America, is nowadays grown in other tropical or subtropical. Request PDF on ResearchGate | On Dec 14, , BA Theiler and others published Identification of Justicia secunda Vahl by IR spectroscopy.

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At each step of the pilot plant process, the co-products obtained were analyzed for total polyphenol and total flavonoid contents by the UV-vis spectrophotometric method. These findings suggest that anthocyanin extracts play a role in both stabilising the red blood cell membrane and inhibiting polymerisation of haemoglobin S.

Vanl has also been postulated that the red cells of patients with sickle cell disease contain a higher than normal concentration of calcium ions.

Anthocyanins extracted from some Congolese plants used in traditional medicine against sickle cell disease have recently been shown to have anti-sickling activity in vitro. Emmel, Itano and osmotic fragility tests were used to test the effect of anthocyanin extracts from Justicia secunda leaves on haemoglobin Sechnda solubility and sickle cell membrane stability.


Justicia secunda

This provides a possible molecular basis for earlier reports on the anti-sickling properties of anthocyanins from some Congolese plants and their use in the management of sickle cell disease by Congolese traditional healers.

Water extracts of Justicia secunda leaves are used by village communities in southern countries to prepare traditional medicines at home. On a pilot plant scale, water extracts were processed using an secundaa procedure achieved in a three-step process, including ultrasound-assisted water extraction followed by cross-flow microfiltration of the crude extract and its concentration by reverse osmosis.

Sickle cell disease or drepanocytosis is caused by the polymerisation of abnormal haemoglobin S when oxygen tension decreases. Treated SS red blood cells recovered a normal, classical biconcave form with a radius of 3.

Polyphenol extraction and characterization of Justicia secunda Vahl leaves for traditional medicinal uses. Justicia secunda is a plant used in Congo by Jehovah’s Secuda, well known for their refusal of blood transfusions, against anaemia.


As the processing conditions were milder than for homemade preparations, the extract obtained was enriched in natural leaf flavonoids.

Anthocyanins from Justicia secunda were found to possess anti-sickling activity. The beverage is usually obtained by boiling the plant in water.

Justicia secunda Vahl, – Overview

Publications des agents du Cirad. Site du Cirad Jusficia des sites du Cirad. The solubility of deoxyhaemoglobin S increased and the osmotic fragility of drepanocytes decreased upon treatment with anthocyanin extracts.

Industrial Crops and Products This lead to the changes in the shape of red blood cells and anaemia.

The process allowed a better leaf water-extraction of polyphenol compounds than the homemade extraction. These ions are bound to membrane proteins resulting in dehydration and loss of red blood cell deformability and cell-to-cell adherence.